Among the most enigmatic figures in biblical literature, the Nephilim fill an intricate mesh of theology, mythology, folklore, cultural memory, contemporary insights into human differentiation etc. The Nephilim themselves only feature lightly in Genesis 6:1-4 and Numbers 13:32-33. Nevertheless, they remain the subject of generations of discussion over their origins, identity, and symbolic significance. This paper re-appraisals the Nephilim drawing upon an interdisciplinary perspective and integrates biblical studies, apocryphal literature, archaeology, folklore, cultural memory theory and Disability Studies. Referencing the Book of Enoch and Book of Giants, the article studies how traditions of giant-like beings first developed as parts of religious narratives and later became enshrined in some of the world’s folklore such as giants, ogres, oni, and trolls. Comparative thinking brings forth recurring themes of power, liminality, fear, transgression, otherness and man’s relationship to the unknown. Although archaeological and scientific evidence bears little out the existence of a prehistoric race of giant humanoids, they are still valuable in symbolic and cultural terms. Specific focus is on giant and monster traditions for special education children, and the way in which these narratives could be utilized in inclusion education, bibliotherapy, narrative therapy and discussions of stigma, diversity, disability identity and social belonging. The paper contends that giants and monsters are not so much historical entities, but also social symbols that culture uses as ways to make sense of what is normal/other/least protected/inclusive. An alternative to the Nephilim perspective would reveal that the stories of ancient peoples maintain a central role in shaping more contemporary paradigms of human diversity and social acceptance.